2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-114164G
    Murine Thrombin 9002-04-4 98%
    Murine Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.
    Murine Thrombin
  • HY-114293A
    Acetyl coenzyme A trilithium 75520-41-1 98%
    Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis.
    Acetyl coenzyme A trilithium
  • HY-114603A
    Efegatran sulfate 126721-07-1 98%
    Efegatran (LY 294468) sulfate is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
    Efegatran sulfate
  • HY-114603B
    Efegatran di(hydrochloride) 173006-83-2 98%
    Efegatran (LY 294468) dihydrochloride is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
    Efegatran di(hydrochloride)
  • HY-114638A
    Diproteverine hydrochloride 69373-88-2 98%
    Diproteverine hydrochloride is an oral activity calcium channel blocker. Diproteverine hydrochloride embryonic toxicity. Diproteverine hydrochloride also shows antianginal properties.
    Diproteverine hydrochloride
  • HY-114794R
    Desglymidodrine (Standard) 3600-87-1
    Desglymidodrine (Standard) is the analytical standard of Desglymidodrine. This product is intended for research and analytical applications. Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure.
    Desglymidodrine (Standard)
  • HY-114950R
    EXP3179 (Standard) 114798-36-6
    EXP3179 (Standard) is the analytical standard of EXP3179. This product is intended for research and analytical applications. EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions.
    EXP3179 (Standard)
  • HY-115839A
    Detajmium L-tartrate 33774-52-6 98%
    Detajmium (L-tartrate) is an antiarrhythmic compound. Detajmium has effect on V max in both dog ventricular muscle and Purkinje fibers was frequency dependent.
    Detajmium L-tartrate
  • HY-116051A
    16,16-Dimethylprostaglandin F2β 59769-89-0 98%
    16,16-Dimethylprostaglandin F2β (16,16-Dimethyl-PGF2β) is an analog of PGF2β (HY-12956B), which is an irratant, but prevents the aspecifically induced bronchospasm.
    16,16-Dimethylprostaglandin F2β
  • HY-116444A
    16-HETE 128914-46-5 98%
    16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease.
    16-HETE
  • HY-116500A
    AH-1058 228123-15-7 98%
    AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes.
    AH-1058
  • HY-116790B
    (±)-Penbutolol 36507-48-9 98%
    (±)-Penbutolol ((Rac)-Penbutolol) is the racemic mixture of Penbutolol. (±)-Penbutolol is an orally active β-adrenergic receptor antagonist. (±)-Penbutolol antagonizes exercise-induced tachycardia, reduces the increase in peak expiratory flow rate (PEFR) caused by exercise, and decreases resting plasma renin activity (PRA). (±)-Penbutolol reaches peak plasma concentration 1 hour after oral administration, with a half-life of 4.5 hours, and is converted into an active metabolite in the body. (±)-Penbutolol can be used in cardiovascular-related disease research.
    (±)-Penbutolol
  • HY-117356B
    MRS2693 trisodium 1448858-83-0 98%
    MRS2693 trisodium is a selective P2Y6 agonist with an EC50 value of 0.015 μM. MRS2693 trisodium can reduce the activation of NF-kappaB and activate the ERK1/2 pathway, and has a cytoprotective effect on mouse hindlimb skeletal muscle ischemia-reperfusion injury model.
    MRS2693 trisodium
  • HY-118202A
    (-)-Gallopamil hydrochloride 36622-39-6 98%
    (-)-Gallopamil (hydrochloride) exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil (hydrochloride) inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil (hydrochloride) also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil (hydrochloride) is promising for research of antiarrhythmics.
    (-)-Gallopamil hydrochloride
  • HY-118472R
    Benazeprilat (Standard) 86541-78-8
    Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
    Benazeprilat (Standard)
  • HY-118628A
    BML264 99196-74-4 98%
    BML264 ((E)-N-(p-amylcinnamoyl) anthranilic acid) is an agonist for TREK-1. BML264 can be used to study diseases associated with TASK1 dysfunction.
    BML264
  • HY-118670A
    16(R)-Iloprost 74843-13-3 98%
    16(R)-Iloprost is a stereoisomer of Iloprost. 16(R)-Iloprost inhibited platelet aggregation with IC50 value of 65 nM.
    16(R)-Iloprost
  • HY-119358R
    Traumatic Acid (Standard) 6402-36-4
    Traumatic Acid (Standard) is the analytical standard of Traumatic Acid. This product is intended for research and analytical applications. Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].
    Traumatic Acid (Standard)
  • HY-119695B
    Simvastatin acid calcium hydrate 530112-57-3 98%
    Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
    Simvastatin acid calcium hydrate
  • HY-119802S
    Practolol-d7 2714414-11-4 98%
    Practolol-d7 is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.
    Practolol-d7
Cat. No. Product Name / Synonyms Application Reactivity